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Call for papers

Prevention and Early Diagnosis of Breast Cancer

We are welcoming submissions to our new collection on prevention and early diagnosis of breast cancer, guested edited by Monica Pernia Marin, Caren Greenstein, and Mary Salvatore.

Submission Deadline:
27 February 2025

Molecular mimicry in human diseases

We are welcoming submissions to our new collection on molecular mimicry in human diseases, guested edited by Luigi Buonaguro and Jamie Rossjohn.

Submission Deadline:
15 December 2024

Article Collections

"Planeterranean" Diet: Globally Extending the Health Benefits of the Mediterranean Diet

Edited by Prof Laura Soldati, Prof Salvatore Nesci, Prof Prisco Piscitelli, Prof Claudia Vetrani,
& Prof Luigi Barrea

Fibrosis and Cancer Intersection

Edited by Dr Mary Salvatore &
Dr Monica Pernia

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Check out the most discussed articles from the previous month!

Meet the Editors

Get to know the Editors behind Journal of Translational Medicine! 

Articles

Featured Research: Cardiopulmonary and metabolic responses during a 2-day CPET in myalgic encephalomyelitis/chronic fatigue syndrome: translating reduced oxygen consumption to impairment status to treatment considerations

Post-exertional malaise (PEM), the hallmark symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), represents a constellation of abnormal responses to physical, cognitive, and/or emotional exertion including profound fatigue, cognitive dysfunction, and exertion intolerance, among numerous other maladies. Two sequential cardiopulmonary exercise tests (2-d CPET) provide objective evidence of abnormal responses to exertion in ME/CFS but validated only in studies with small sample sizes. Further, translation of results to impairment status and approaches to symptom reduction are lacking. Presently, this is the largest 2-d CPET study of ME/CFS to substantiate impaired recovery in ME/CFS following an exertional stressor.

Featured Review: Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease with a broad overlap of symptomatology with Post-COVID Syndrome (PCS). Despite the severity of symptoms and various neurological, cardiovascular, microvascular, and skeletal muscular findings, no biomarkers have been identified. The Transient receptor potential melastatin 3 (TRPM3) channel, involved in pain transduction, thermosensation, transmitter and neuropeptide release, mechanoregulation, vasorelaxation, and immune defense, shows altered function in ME/CFS. We propose that TRPM3 dysfunction may have a broader involvement in ME/CFS pathophysiology, affecting other organs. This paper discusses TRPM3’s expression in various organs and its potential impact on ME/CFS symptoms, with a focus on small nerve fibers and the brain, where TRPM3 is involved in presynaptic GABA release.

Journal of Translational Medicine has launched In Review, a new option that provides authors with on-demand information on the status of their manuscript, enables them to share their work with funders and their research community, and allows their colleagues to comment and collaborate - all whilst their manuscript is under review.

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Featured section: Neuroscience

The Neuroscience section aims to encourage publications that help to reduce the gap between basic preclinical science and medical applications for the patients in the neuroscience field. Any new tool for the dissemination of results in the field can greatly help to progress in the new solutions for the neuropsychiatric patient. The section aims to promote the increase of knowledge on the subject by publishing original research. 

Read the latest articles in the Neuroscience section

Introducing new sections to Journal of Translational Medicine!

Regenerative Medicine

Led by Section Editor Francisco Silva, the Regenerative Medicine section aims to bring together experts across research disciplines (such as biology, chemistry, computer science, engineering, genetics, medicine, and robotics) in order to find new solutions towards therapies. The clinically disruptive field of regenerative medicine encompasses various strategies including the use of materials and biologics to take the place or remodel compromised tissues both structurally and functionally in order to facilitate tissue healing.

The section welcomes research focused on advancing the various technologies that encompass regenerative medicine to aid in the development and translation of novel therapies for those suffering from unmet medical needs. 

Molecular Pathology

Led by Section Editor Sarah Warren, the Molecular Pathology section aims to highlight studies that characterize human-derived biological materials, including both tissue and liquid biopsies, using molecular profiling techniques to elucidate the underlying causes of disease and impacts of therapeutic interventions. 

The Molecular Pathology section will consider studies that are preclinical or translational in nature, as well as from all stages of fundamental and applied research. The section welcomes manuscripts that describe new technology platforms that advance molecular profiling or novel computational approaches to support data analysis.

Network Medicines

Led by Section Editor Joyce Hu, the Network Medicines section is dedicated to the biology-based, integrative approach aimed at understanding the topology of complex disorders and the dynamic interplay of their various components, identifying cascades of causes and effects, listening to cross-talks among cells to suggest novel and more effective therapeutic approaches.

The section welcomes research that goes beyond descriptive observations and provides compelling recommendations of disruptive therapeutic candidates.

Translational Process

© smolaw11 / stock.adobe.comLed by Marina Boccardi, the Translational Process section welcomes contributions aimed to streamline the transition of new knowledge along the translational continuum, and boost our ability to concretely innovate clinical practice. 

The Translational Process section dedicates a space to those who tackle such challenges overcoming the boundaries of individual disciplines, and offers a new opportunity to share and accelerate the development of urgently needed methods, tools and procedures. 

Editor-in-Chief: Francesco Marincola, Sonata Therapeutics, USA

Franco Marincola is the Chief Scientific Officer of Sonata Therapeutics. Franco brings over 30 years of research and development experience in immunology, oncology and cell therapy to Sonata.

Most recently, Franco served as Senior Vice President and Global Head of Research at Kite Pharma where he led the research organization to identify novel therapies for hematologic malignancies and solid tumors. Prior to Kite, he was President and Chief Scientific Officer at Refuge Biotechnologies, where he developed research strategies for adoptive cell therapy products and led therapeutic programs based on nuclease deactivated CRISPR circuits. Prior to Refuge, Franco was Distinguished Research Fellow in Immune Oncology at AbbVie, and Chief Research Officer at Sidra Medical and Research Centre.

Before joining the biopharma industry, Franco spent more than two decades at the National Institutes of Health (NIH) and National Cancer Institute (NCI), most recently as a tenured senior investigator in cancer immunotherapy and biomarker research and as Chief Infectious Disease and Immunogenetics Investigator at the NIH Clinical Center.

Franco is the former President of the Society for Immunotherapy of Cancer (SITC). He currently serves as Editor-in-Chief for multiple peer-reviewed publications, including Journal of Translational Medicine, Translational Medicine Communications, and Immunotherapy, and is the author of more than 600 peer-reviewed publications.

Franco received his M.D. from the University of Milan and completed his residency at Stanford University.

Aims and scope

Journal of Translational Medicine is an open access journal publishing articles focusing on information derived from human experimentation so as to optimise the communication between basic and clinical science.

The journal covers all areas of translational medicine but also has several special sections:


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